Evaluación del crecimiento fetal por ultrasonografía; relación con los resultados neonatales inmediatos
Resumen
El crecimiento fetal humano es un proceso muy
complejo que se determina en el tiempo y en donde
interactúan factores intrínsecos y extrínsecos. Un
buen diagnostico ecografico del crecimiento fetal humano
es importante, ya que el presente y futuro del
recién nacido esta íntimamente ligado a esta etapa
de la vida. Uno de los riesgos bien conocidos es la
restricción del crecimiento intrauterino que llega al
10% en poblaciones de riesgos y se observa en un
5% en la población general. Para poder detectarlo,
debemos estudiar todo el entorno fetal, a la madre,
medir (biometrías)las distintas partes anatómicas del
feto. Las anormalidades en el crecimiento y desarrollo
fetal, es conocido por su bajo peso al nacer, mayor
morbilidad y mortalidad. Tienen mayor deterioro
de su calidad de vida futura. Objetivo: conocer la
concordancia entre la edad gestacional por la fecha
de la última menstruación y la ecografía. Determinar
el porcentaje de pacientes que presentan diferencias
en 1 - 2 y 3 semanas entre la fecha de última regla y
el examen ecografico de primero, segundo y tercer
trimestre, estos resultados a su vez relacionar con el
test de Capurro. Determinar la frecuencia de diferencias
Material y método: El estudio es descriptivo
temporalmente prospectivo de casos consecutivos en
una población de 161 mujeres grávidas con feto único
que asistieron al Centro Materno Infantil de Hospital
de Clínicas para su evaluación ecográfica, sumaron
322 observaciones, con los criterios de inclusión preestablecidos
durante los años 2002 al 2004, luego se
relacionó con los resultados neonatales inmediatos
para valorar las patologías detectadas y contribuir
al manejo oportuno y adecuado. Muestreo no probabilístico
de casos consecutivos. Resultados: En
el primer trimestre de la gestación la concordancia
entre la clínica, el examen ecografico y el test de Capurro
fue de 88 y 86% para diferencias de 1 semana.
91 y 92% si la diferencias llegan a 2 semanas. En
el segundo trimestre, los hallazgos de concordancia
entre la clínica y la ecografía, este a vez con el test
de Capurro fue de 84 y 73%. En cambio llegó a 92
y 93% si la diferencia eran 2 semanas. Para un nivel
de confianza del 90% El crecimiento fetal observado
por trimestres mostró variaciones de incrementos
de casos del p 3 y p10. Conclusiones: Los recién
nacidos, 81% adecuados para la edad gestacional,
observación igual al prenatal. 13% pequeños para la
edad gestacional. 6% grandes o macrosomicos.
Estas anormalidades se asociaron a morbilidades del
15.5%(n=25) que requirió el ingreso a terapia intensiva.
Palabras clave
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PDFReferencias
- Albaigés Gerard. Frontera entre feto pequeño para la
edad gestacional restricción de crecimiento. Gineco -
Obstet Clin.2004; 5(1):8-21.
- Pittaluga E, Diaz A V, Mena NP, Corvalán VS. Curva
de crecimiento intrauteino. .Rev Chil Pediatr 2002; 73
(2): 135-141.
- Villar j. Belizan JM. The timing factor in the pathophisiology
of the intrauterine growth retardation syndrome.
Obstet Gynecol Survey.1982;37:499-506.
- Spirt BA, Gordon LP. The placenta as an indicator of
fetal maturity: fac and ancy. Semin Ultrasound 1984;
: 290- 297
- Lubchenco O, Hansman CH, Dressier M, Boyd E.
Intrauterine growth as estimated from liverborn birhweight
data at 24 to 42 weeks of gestation. Pediatric
;32:793-800.
- Filly RA, Golbus MS, Carrey JC et al. Short-limbet
dwarfism: ultrasonographic diagnosis by mensuration
of fetal femoral length.Radiology 1981;138:653-656.
- Chevernak FA, Rosenberg J, Brightman RC et al. A
prospective study of the accuracy of ultrasound in predicting
fetal microcephaly. Obstet Gynecol.1987;69:
-910.
- American Institute of Ultrasound in Medicine. Guidelines
for performance of the antepartum obstetrical
ultrasound examination. J Ultrasound Med
;185:15-20.
- Doubilet PM, Benson GB, Nadel AS, Ringer SA.
Improved birth weight table for neonates developed
from gestations dated by early ultrasonography. J Ultrasound
Med 1997;16:241-249.
- Hutchins GL. Delivery of the growth-retarded infant.
Obstet Gynecol 1980;56: 683-686.
- Deter RL, Hadlock FP, Use of ultrasound in the detection
of macrosomía: a review. J Clin Ultrasound.
; 13:519-524.
- Elliot JP, Garite TJ,Freemen RK et al. Ultrasonic prediction
of fetal macrosomía in the diabetic patients.
Obstet Gynecol 1982; 60: 159-162.
- Durkan JP, Russo GL. Ultrasonic fetal cephalometry.
Accuracy, limitations, and applications. Obstet Gynecol
; 27: 399 -403.
- Hohler CW, Inglis J, Collins H et al. Ultrasound biparietal
diameter: Defining relationship in normal pregnancy.
NY State J Med 1976; 76:373-375.
- Campbells. An improved method of fetal cephalometry
by ultrasound. Br J Obstet Gynecol Br Cwith1968;
: 568.-570
- Kurtz AB, Wapner RJ,Kurtz RJ,Dershaw DD, Rubin
GS et al. Analysis of biparietal diameter as an accurate
indicator of gestational age. J Clin Ultrasound 1980;8:
-326.
- Hadlock RP, Deter RL, Harris RB, Park SK. Fetal
biparietal diameter: A critical re-evaluation of the relation
to menstrual age by means of real time ultrasound.
J Ultrasound Med 1982; 1: 97-104.
- Pellicer A, Calatayud C, Miro F et al. Comparison of
implantation and early development of human ambryos
fertilized in vitro vs in vivo using transvaginal ultasound.
J Ultras Med 1991; 10 (1): 31-35
- Drumm JE, The prediction of delivery dates by ultrasonic
measurement of fetal crown- rump length. Br J
Obstet Gynecol 1977; 84:1-5.
- Campbell S, Warsof SL, Little D et al. Routine ultrasound
screening for the prediction of gestational age.
Obstet Gynecol 1985;65:613-620
- Kopta MM. May RR, Crane JP, A comparison of the
reliability of the estimated date of confinement predicted
by crown-rump length and biparietal diameter.
Am J Obstet Gynecol 1983; 145: 562-565.
- Smazal SF, Weisman LE, Hoppler KD et al. Comparative
analysis of ultrasonographic methods of gestational
age assessment. J. Ultrasound Med. 1983;2:
- Campbell S. The prediction of fetal maturity by ultrasonic
measurement of the bi parietal diameter J Obstet
Gynecol Br Cwith 1987; 156: 955-957.
- Sabbaga RE, Minogue J, Tamura RK et al. Estimation
of birthweight by use of ultrasonographic formulas
targeted to large-appropriate-and small-for-gestational-
age fetuses? Am J Obstet Gynecol 1989; 160:
-862
- Shepard M Filly RA.. A standardized plane for biparietal
diameter measurement J Ultrasound Med
;1: 145-147
- Usher R, McLean F. Intrauterine growth of live born.
Caucasian infants at sea level: Standars of gestation.
Pediatrics 1969;74: 901-910.
- Hadlock FP, Deter RL, Carpenter RJ, Park SK. Estimating
fetal age: Effect of head shape on DBP. AJR
;137:83-85.
- Babson SG, Benda GL. Growth for the clinical assessment
of infants of varying gestational age. Pediatrics
; 79: 139-143.
- Warsof SL, Cooper DJ, Little D et al. Routine ultrasound
screening for antenatal detection of intrauterine
growth retardation. Obstet Gynecol 1986; 67:33-39.
- Dubowitz LMS, Goldberg C. Assessment of gestation
by in infants differing in size and ethnic origin. Br. J
Obstet Gynecol 1998; 105: 1329-1331
- Warda AH, Deter RL, Rossavik IK et al. Fetal femur
length: A critical reevaluation of the relationship to
menstrual age. Obstet Gynecol 1985; 66:69.-75
- Hadlock FP, Harrist RB, Deter RL, et al. A prospective
evaluation of fetal fémur length as a predictor of
gestational age. J. Ultrasound Med. 1983; 2: 111-112.
- Hadlock FP, Harrist RB, Martinez- Poyer J: In utero
analysis of fetal growth: A sonographic weight standard.
Radiology 1991; 181: 129-133.
- Centurión Bogado A. Tesis. FCM. U.N.A. 1983 Tomo
:272-321
- Peris MA, Martínez NO, et al. Determinación de la
edad gestacional por longitud de fémur. V Congreso
Paraguayo de Ginecología y Obstetricia. 1984;1:439-
- De Onis N , Blosner N, Villar J. Levels and Patterns
of intrauterine grouth retardation in developing countries.
European Journal of Clinical Nutrition 1998; 52:
-16.
- Barros FC, Victoria CG. Increased blood pressure adolescents who were small for gestational age at birth:
a cohort study in Brazil. International Journal of Epidemilology
; 28: 676-681.
- Timor- Tritsch IE, Bar- Yam Y, Elgali S, Rottem
S: The technique of transvaginal sonography with
the use of a 6,5 MHZ probe. Am J Obstet Gynecol
;158:1019-1024.
- Frederick JL, Paulson RJ, Sauer MV: Routine use of
vaginal ultrasonography in the preoperative evaluation
of gynecology patiens: An adjunct to resident
education. J Reprod Med. 1991; 36: 779-782.
- Peissner DB. Transvaginal sonography Equipment..
En: Timor – Trisch IE, Rottem S, editores. Transvaginal
Sonography. 2ed. New York: Elsevier; 1991. 29-
- Goldstein SR: Incorporating endovaginal ultrasonography
into the overall gynecological examination.
Am J Obstet Gynecol 1990; 162:625-632.
- Moore KL. The fetal period the ninth week to birth. In
Moore KL., editor. The Developing Human:Clinically
Oriented Embryology, 4 ed. Philadelphia: WB
Saunders;1988. 65-86
- Timor – Tritsch IE, Farine D, Rosen MG. A Close
look at early embryonic development with the high –
frequencies transvaginal. Am J Obstet Gynecol 1988;
:676-681.
- Filly RA, Ectopic pregnancy: the role of sonagraphy.
Radiology 1987; 162: 661- 668.
- Nyberg DA, Filly RA, Duarte – fiho DL et al Early
gestation; correlation of HCG levels and sonographic
identification. AJR 1985; 144: 951-954.
- Kramer S. Determinación of low birth weigth methodological
assesment and meta analisys. Bull World
Health Organization 1987;66:737.
- Keith SC, London SN, Weitzman GA et al. Serial
transvaginal ultrasound seans and beta- human chorionic
gonadotropin levels in early singleton and multiple
pregnancies. Fertil Steril 1993; 59: 1007- 1010
- Nyberg DA, Filly RA, Duarte – fiho DL etal Abnormal
pregnancy early diagnosis by US and Serum chorionic
gonodotopin levels Radiology 1986; 158:393- 396.
- Nyberg DA, Mack L, Laing FC et al. Early pregnancy
complications endovaginal sonography finding correlated
with human chorionic gonadotropin levels. Radiology
; 167: 619-622
- Mantoni F, Pedersen JF. Ultrasound visualization of
the human yolk sac. JCU 1979; 7: 459-465
- Warren WB,Timor Tritsch I, Peisner DB, Raju S, Rosen
MG: Daiting The early pregnancy by sequential
apperence of embryonic structures. Am J Obstet Gynecol
; 161: 747-753.
- Levi CS, Lyons EA, Linsay DJ. Ultrasound in the first
trimester of pregnancy. Radiol Clin North Am 1990;
: 19-38
- Drumm JE the prediction of delivery date by ultrasonic
measurement of fetal crown rump length Br J
Obstet Gynecol 1975; 82:702-710
- Smazal SF, Weisman LE, Hoppler KD et al. Compararive
analysis of ultrasonographic methods of gestational
age assessnent J Ultrasuond Med 1983;2:147-149
- Kopta MM, May RR, Crame JP. A Comparison of the
reliability of the estimated date of conjinement predicted
by crown – rump lenght and biparietal diameter.
Am J Obstet Gynecol 1983; 145:562-565
- Levi CS, Lyons EA, Zheng XH et al. Endovaginal
US. Demonstration of cardiac activity in embryons of
less than 5.0 mm in crown- rump length. Radiology
; 176: 71- 75.
- Robinson HP Sonar measurement of fetal crown rump
lenght as means of assessing maturity, of first trimester
of pregnancy. Br Med J 1973; 4(19):28-31
- Pedersen JF. Fetal crown-rump lenght measurement
by ultrasound in normal pregnancy. Br. J Obstet Gynecol
; 89: 926-930
- Daya S, Woods S, Ward S, Lappalainen R, Caco C.
Early pregnancy assessment with transvaginal ultrasound
scanning. Can Med Assoc J 1991; 144: 441-
- Van de Velde EHE, Broeders GHB, Hor-bach JGM et
al. Estimation of pregnancy duration by means of ultrasonic
measurements of the fetal crown-rump length.
Eur J Obstet Gynecol Reprod Biol 1980; 10:225-230
- Pedersen JF. Ultrasound evidence of sexual difference
in fetal size in first trimester. Br Med J 1980;
:1 – 263
- Jain KA, Hamper UM, Sanders RC. Comparison of
transvaginal and transabdominal sonography in the
detection of early pregnancy and complications. AJR
;151: 1139- 1143.
- Doubilet PM, Benson CB. Embyonic heart rate in the
first trimester. What rate is normal? J Ultra Med 1995;
:431 – 434
- Benacerraf BR. Intrauterine Growth retardation in the
first trimester associated with triploidy . J Ultra Med
;7(3):153-154.
- Bree RL, Edwars M, Bohm Velez M et al. Transvaginal
sonography in the evaluation of normal early
pregnancy:correlation with HCC level. AJR 1989;
: 75-79.
- Jain KA, Hamper UM, Sanders RC. Comparison of
transvaginal and transabdominal sonography in the
detection oof early pregnancy and its complications
AJR 1988;151:1139-1143
- Robinson HP, Fleming JEF. A critical evaluation of
sonar “ crown-rump length” measurements. Br J Obstet
Ginecol 1975;82: 702-710
- Filly RA. Appropriane use of ultrasound in early pregnancy.
Radiology 1988; 166: 274-275
- Kurtz AB, Needleman I. Ultrasound assessment of
fetal age. In Callen PW, editor. Ultrasonography in
Obstetric and Gynecology. 2 ed. Philadelphia: WB
Saunders: 1988.47-64.
- Bovicelli L, Orsini LF, Rizzo N, et al: Estimation of
gestational age during the trimester by realtime measurement
of fetal crown- rump length and biparietal
diameter. J Clin Ultrasound 1981; 9: 71-75
- Mc Gregor SN, Tamara RK, Sabbagha RE, et al. Under-
estimation of gestational age by conventional crwn-
rump length dating curves. Obstet Gynecol 1987;
: 344-348
- Wald NJ. Cuckle HS, Densem JW et al. Maternal
serum screening for Down’s syndrome in early pregnancy. Br Med J 1988;8: 883-887
- Keith SC, O Brien TJ, London SN et al. Serial transvaginal
ultrasound scans and B- human chorionic
gonadotropin levels in early singleton Fertil Steril
;59: 1007-1010.
- Canick JA, Knight GJ, Palomaki GE et al. Low second
trimester maternal serum un conjugated o estriol
in pregnancies with Dow’s syndrome. Br J Obstetric
Ginecol 1988; 95: 330-333
- Kurtz AB, Wapner RJ, Kurtz RJ, et al. Analysis of biparietal
diameter as an accurate indicator of gestational
age. J Clin Ultrasound 1980; 8: 319-326.
- Nelson LB. Compararison of methods for determining
crown- rump measurement by real – time ultrasound.
J Clin Ultrasound 1981; 9: 67-70.
- Law RC, Mac Rae KD, Head circumference as an index
of fetal age. J Ultrasound Med 1982; 1: 281-288
- Hadlock FP, Deter RL, Harrist RB et al. Fetal abdominal
circumference as a predictor of menstrual age.
AJR 1982; 139: 367-370
- O Brien FD, Queenan JT, Campbell S. Assessment of
gestational age in the second trimester by real time
ultrasound measurement of the femur length, Am J
Obstet Gynecol 1981; 139: 540-545.
- Hadlock FP, Deter RL, Harrist RB et al. Estimulating
fetal age:computer-assisted analysis of múltiple
growth parameters. Radiology 1984;152:497-501
- Jeanty PJ, Rodesch F, Delneke D, et al. Estimation
of gestational age from measurements of fetal long
bones. J Ultrasound Med 1984;3: 75-79.
- Chity LS, Altman DG: Charts of fetal size limb bones.
BJ OG 2002;109:919- 920
- Jeanty P, Cantraine F, Cousaert E et al. The binocular
distance:a new way to estimate fetal age. J Ultrasound
Med 1984;3:241-243.
- Jun Zhang MB, Bones WA. Birth-weight for gestational
age pattern by race, sex and parity in the United
States of America. Obstet Gynecol 1995; 86: 200-8
- Hadlock FP, Deter RL, Harrist RB et al. Computer assisted
analysis of fetal age in the third trimester using
múltiple fetal growth parameters. J Clin Ultrasound
;11: 313-316.
- Hadlock FP, Deter RL, Harrist RB et al. Fetal biparietal
diameter: rational choice of plane of section for
sonographic measurement. A J R 1982;138: 871-874
- Doubilet PM, Grenees RA. Improved prediction of
gestational age from fetal head measurements. AJR
;142: 797-800.
- Hadlock FP, Kent WR, Loyd JL, et al. An evaluation
of two methods for measuring fetal head and body
circumferences. J Ultrasound Med 1982;1: 359-360
- Gray DL, Sonster GS, Parvin CA, Crane JP. Cephalic
index : A gestational age dependent biometrics parameter.
Obstet Gynecol 1989;74:600-605
- Shepard M, Filly RA. A standardized plane for biparietal
diameter measurement. J Ultrasound Med
;1: 145 -150
- Kasby CB, Poll V. The breech head and its ultrasound
significance. Br J Obstet Gynaecol 1982; 89:106 -
- Wolfson RN, Zador IE, Halvorsen P et al. Biparietal
diameter in premature rupture of membranes: Errors
in estimating gestational age. J Clin Ultrasound 1983;
: 371-376.
- Doubilet PM, Benson CB, Improved prediction of
gestational age in the late third trimestre. J Ultrasound
Med 1993; 12: 647-653
- Goldstein RB, Filly RA, Simpson G. Pitfalls in femur
length measurements. J Ultrasound Med 1987; 6: 203-
- Jeanty PJ, Rodesch F, Delbeke D, et al. Estimation of
gestational age from measurements of fetal long bones.
J Ultrasound Med 1984;3:75-79
- Hadlock FP, Deter RL, Harrist RB et al. Estimulating
fetal age: computer-assisted analysis of multiple
growth parameters. Radiology 1984;152: 497-501
- Hadlock FP, Deter RL, Harrist RB et al. Computer assisted
analysis of fetal age in the third trimester using
multiple fetal growth parameters. J Clin Ultrasound
;11: 313-316
- Doubilet PM, Benson CB, Improved prediction of
gestational age in the late third trimester. J Ultrasound
Med 1993; 12: 647-653
- Benson CB, Doubilet PM. Fetal measurements for
predicting gestational age in the second and third trimesters:
a reappraisal with a more reliable gold standard.
Radiology 1988;169 :210.- 216
- Campbell S. Wilkin D. Ultrasonic measurements of
fetal abdominal circumference in the estimation of fetal
weight. Br J Obstet Gynecol 1975; 82: 689-697
- Vintzileos AM, Campbell WA, Rodis JF et al. Fetal
weight estimation formulas with head, abdominal,
femur and thigh circumference measurements. Am J
Obsted Gynecol 1987; 157: 410-414
- Townsend RR, Filly RA, Callen PW et al. Factors
affecting prenatal sonographic estimation of weight in
extremely low birhweight infants. J Ultrasoun Med.
;7:183-187
- Hadlock FP, Harrist RB, Carpenter RJ et al. Sonographic
estimation of fetal weight: the value of femur
length in addition to head and abdomen measurements.
Radiology 1984; 150: 535-540
- Hadlock FP, Harrist RB, Sharman RS et al. Estimation
of fetal weight with the use of head, body, and femur
measurements: a prospective study. Am J Obsted
Gynecol 1985; 151: 333-337
- Benacerral BR, Gelman R. Frigoletto FD Sonographically
estimated fetal weight: accuracy and limitation.
Am J Obstet Gynecol 1988; 159:1118 – 1121.
- Doubilet PM, Benson CB, Nadel AS, Ringer SA.
Improved birth weight table for neonates developed
from gestations dated by early ultrasonographic. J Ultrasound
Med 1997; 16: 241-249
- Hutchins CJ. Delivery of the growth-retarded infant.
Obsted Gynecol 1980; 56: 683-686.
- Mintz MC, Landon MB. Sonographic diagnosis of
fetal growth disorders. Clin Obstet Gynecol 1988; 31:
-52
- Boyd ME, Usher RH, McLean FH. Fetal macrosomía:
prediction, risks, proposed management. Obstet
Gynecol 1983; 61: 715-722
- Deter RL, Hadlock FP. Use of ultrasound in the detection of macrosomía: a review. J Clin Ultrasound 1985;
: 519-524
- Ott WJ. The diagnosis of altered fetal growth. Obstet
Gynecol Clin North Am 1988; 15: 237-263
- Golditch IM, Kirkman. The large fetus: management
and outcome. Obstet Gynecol 1978; 52: 26-30
- Arias F. Predictability of complications associated
with prolongation of pregnancy. Obstet Gynecol
; 70: 101-106
- Miller JM, Korndorffer FE, Gabert HA. Fetal weight
estimates in late pregnancy with emphasis on macrosomía.
J Clin Ultrasound 1986; 14: 437-442
- Miller JM, Kissling GA, Brown HL et al. Estimated
fetal weight: applicability to small – and large-forgestational-
age fetus. J Clin Ultrasuond 1988; 16:
-97
- Doubiled PM, Benson CB. Fetal growth disturbances.
Semin Roentgenol 1990; 25: 309-316
- Miller JM, Brown HL, Khawli OF et al. Ultrasosographic
identification of the macrosomic fetus. Am J
Obsted Gynecol 1988; 159: 1110-111
- Landon MB, Mintz MC, Gabbe SG. Sonographic
evaluation of fetal abdominal growth: predictor of the
large-for-gestational-age infant in pregnancies complicated
by diabetes mellitus. Am J Obstet Gynecol
; 160: 115-121
- Elliot JP, Garite TJ, Freeman RK et al. Ultrasonic
prediction of fetal macrosomía in diabetic patients.
Obstet Gynecol 1982; 60: 159-162
- Acker DB, Sachs BP, Friedman EA. Risk factors for
shoulder dystocia. Obstet Gynecol 1985; 66: 762-768
- Kramer MS, Oliver M, Mc Lean FH, et al. Impact
of intrauterine growth retardation body proportionality
on fetal and neonatal outcome. Pediatrics 1990;86:
-713.
- Lockwood CJ, Weiner S. Assessment of fetal growth.
Clin Perinatol 1986; 13: 3-35
- Mc Intire DD, Bloom S, Casey BM, Leveno KJ. Birth
weigth in relation to morbidity and mortality am newborn
infants. N Eng J Med 1999; 340: 1234-1238.
- Mc Cowan LM, Erskine LA, Ritchie K. Umbilical
artery Doppler blood flow studies in the preterrm,
small- for gestational- age fetus. Am J Obstet Gynecol
; 156: 655-659.
- Berkowitz GS,Mehalek KE,Chitkara U et al. Doppler
umbilical velocymetry in the prediction of adverse
outcome in pregnancies at for intrauterine growth retardation.
Obstet Gynecol. 1988; 71: 742-746.
- Reuwer PJH, Sijimons EA, Reitman GW et al. Intrauterine
growth retardation:
prediction of perinatal distress by Doppler ultrasound.
Lancet 1987; 2: 415-418
- Illyes M, Gati I. Reverse flow in the human fetal descending
aorta as a sign of severe fetal asphyxia preceding
intrauterine death. J Clin Ultrasound 1988;16:
-407
- Trudinger BJ, Giles WB, Cook CM. Flow velocity
waveforms in the maternal uteroplacental and fetal
umbilical placental circulations. Am J Obstet Gynecol
;152: 155-163
- Doubilet PM, Benson CB. Sonographic evaluation of
intrauterine growth retardation. AJR 1995;164:709-
- Onis, Blosner N, Villar J. Levels and Patterns of intrauterine
grouth retardation developing countries.
European Journal of Clinical Nutrition 1998;28: 676-
- Cloherty, J.,Stark A. Manual de Cuidados Neonatales.
;269: 379 -384
- Martínez N O, Peris M A, Castiglioni ME. Bajo Peso
al Nacer. Etiología y factores predisponentes. VI Congreso
Paraguayo de Ginecología y Obstetricia II de
Perinatología. III tercer encuentro latinoamericano
FLASOG 1988;5:191-209
- Lomuto C. Diagnóstico de situación perinatal de la
República Argentina en el principio de los 90. Rev.
Hosp. Mat. Inf. Ramón Sardá 1994; 12: 3-11.
- Estadísticas de la región. Bajo peso al nacer. Situación
de la salud en las América. Noviembre 2001.
www.clap.hc.edu.uy
- Di Martino C. Análisis de la mortalidad perinatal en
Paraguay. X Congreso Paraguayo de Gineco-Obstetricia.
VI Congreso Paraguayo de Perinatología. 2004;
: 131-139
- Nunes de M.E. Mortalidade Perinatal. En Medicina
Perinatal San Pablo 2000;60:470-472
- Thurneau GR, Tamura RK, Sabbagha R et al. A
simple estimated fetal weight equation based on
real-time ultrasound measurements of fetus less than
thirty –four weeks gestation. Am J Obstet Gynecol
;145:557-561
- Rizzo G, Capponi A, Soragaroli M et al. Umbilical
vein pulsations and acido base status at cordocentesis
in growth-retardet fetuses with absent end diastolic
velocity in the umbilical artery. Biol Neonate 1995;
:163-168
- Galan HL, Hussey MJ, Chung M, Chyu JK, Hobbins
JC, Battaglia FC. Doppler velocimetry of growth retarded
fetuses in an ovine model of placental insufficiency.
Am J Obstet Gynecol 1998;178: 451-6.
- Gili RW, Trudinger BJ,Garrett WJ, Kossoff G,
Warren PS. Fetal umbilical venous flow measured
in utero by pulsed doppler and B-mode ultrasound .I
Normal pregnancies. Am J Obstet Gynecol. 1981;139:
-725.
- Lagos SR, Espinoza GR, Echeverría GP, Orellana JJ.
Gráfica de crecimiento fetal normal ¿estandar regional
generslizado o estandar general individualizado?
Rev Hosp Mat INF Ramon Sardá 2004; 23: 11-15.
-Juez G, Lucero E, Ventura –Juncá P. Crecimiento
intrauterino según sexo fetal y paridad materna. Rev
Chil Pediatr 1989;69: 204-207
-Juez G, Lucero E, Ventura-Juncá P.Tapia JL, González
H, Winter A. Crecimiento intrauterino en recién
nacidos chilenos de la clase media. Rev. Chil. Pediatr
;60: 198-202.
- Morselli M, Gardosi J. Longitudinal study of fetal
growth in subgroups of a low risk populations. Ultrasound
Obstet Gynecol 1995;6: 340-344.
- Lagos RA, Espinoza RH, Orellana JJ Antropometría
materna y peso promedio de nacimiento. Rev. Chil
Obstet and Ginecol 2001;66 (2): 99-103.
- Naeye RL. Teenaged and pre-teenaged pregnancies:
consequences of the fetal-maternal competition for
nutrients. Pediatrics 1981;67: 146-150.
- Frisancho AR, Matos J, Leonard WR, Yaroch LA.
Developmental and nutritional determinants of pregnancy
outcome among teenagers. Am J. Phys Anthropol
;66: 247-261.
- Sung J. Heat production and neurodevelop mental
outcome of very low birth weigth infant with intrauterine
growth retardation comparison with control
subject mached by birth weigth am gestational age J
Pediatric 1993; 123: 618-624.
- González de Dios J, Moya M, Herranz Y, Sirvent
MC, Cerezo del Olmo Y. Relación entre el incremento
ponderal de la gestante adolescente y el peso del recién
nacido. An Esp Pediatr 1995;42:350-354.
- Elsas LJ, Endo F, Strumlauf E, Elders J, Priest JH.
Lepreuchanism: an inherited defect in a high affinity
insulin receptor. Am J Hum Genet 1985;37: 73-88.
- Stoffer DA, Zinkin NT, Stanojevic V, Clarcke WL,
Habener JF. Pancreatic agenesis attributable to a single
nucleotide deletion in the human IPF 1 gene coding
sequence. Nature Genel.1997;15: 106-10.
-. Hattersley AT, Beards F, Ballantylle E, Appleton
M, Harvey R, Ellard S. Mutation in the glucokinase
gene of the fetus result in reduced birth weight. Nature
genetics1998;19:268-70.
- Desai M, Crowther NJ, Ozanne SE, Lucas A, Hales
CN. Adult glucose and lipid metabolism may be programmed
during fetal life. Biochem Soc Trans 1995;
: 331-5.
- Barker DJP, Osmond C, Golding J, Kuh D, Wadsworth
MEJ. Growth in utero, blood pressure in childhood
and adult life, and mortality from cardiovascular disease.
BMJ 1989; 298 : 564-7.
- Hales CN, Barker DJP, Clark PMS et al. Fetal and
infant growth and impaired glucose tolerance at age
BMJ 1991; 303 : 1019-22.
- Barker DJP, Ericksson JG, Forsen T, Osmond C. Fetal
original of adult diseases: strengths, effects and biological
basis. Int J. Epidemiol 2002; 31: 1235-1239.
- Battaglia FC, Lubchenco LO. A practical classification
of newborn infants by weight and gestational age.
Journal of Pediatric 1967;71: 159-163
- Gruenwald P. Growth of the human fetus. Am J Obstet
Gynec 1966;94:1112-18.
- Brenner WE, Edelman DA, Hendricks CH. Astandard
of fetal growth for the United States of America.
Am J Obstet Gynecol 1976;126:555-64
- Juez G. Curva de crecimiento intrauterino para el
diagnostico apropiado del retardo del crecimiento intrauterino.
Rev Med Chil 1989; 117;1311-1316.
- Juez G G, Opazo M A y Lucero MEF. Influencia de
la talla materna sobre el crecimiento fetal. Rev Chil
Obstet Gynecol 1990;55( 2):104-108.
- Lagos R, Espinoza RH, Orellana JJ. Asociación entre
estado nutritivo materno y crecimiento fetal. Rev Med
del Sur Dic. 2000;22:1-2
-Xiong Xu, Buekens P, Sophie A, Anemia during pregnancy
and birth outcome: A metasnalysis. Am J Perinat
;17: 137-145.
- Weeks AJ. Does the presence of risk factors influence
the perinatal outcome? Am J Obstet Gynecol
;17:1003-1007.
- Herrera JA, Moreno CH. Comportamiento gráfico de
la presión arterial diastólica en gestantes con riesgo de
preeclampsia. Colomb Med 2000;31:158-163.
- Hytten F. Blood volume changes in normal pregnancy.
Clin Haematol 1985;14:601- 611.
- Garn M, Keating MT, Falkner F. Hematological status
and pregnancy outcome. Am J Clin Nutr 1981;34:115-
- Herrera JA. Resultados aplicación del modelo biopsicosocial
en Colombia. En: aplicación de un modelo
biopsicosocial para la reducción de la mortalidad materna
y perinatal en Colombia. 2ed. Bogotá: Ministerio
de Salud – Universidad del Valle; 2000. 169-172.
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Facultad de Ciencias Médicas. Universidad Nacional de Asunción